Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000771)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Desloratadine Product 6-hydroxydesloratadine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000770 Desloratadine 5-hydroxydesloratadine Oxidation - Hydroxylation Desloratadine [1]
MR000769 Desloratadine Desloratadine N-glucuronidation Conjugation - Glucuronidation Desloratadine [2], [1]
MR006904 Desloratadine Desloratadine glucuronide Conjugation - Glucuronidation Loratadine [1]
References
1 A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement Drug Metab Dispos. 2015 Apr;43(4):523-33. doi: 10.1124/dmd.114.062620.
2 Further characterization of the metabolism of desloratadine and its cytochrome P450 and UDP-glucuronosyltransferase inhibition potential: identification of desloratadine as a relatively selective UGT2B10 inhibitor. Drug Metab Dispos. 2015 Sep;43(9):1294-302.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.