Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000787)
Formula
SVG example
Reactant Deutetrabenazine Product Cis (2,3)-Dihydro Tetrabenazine-d6
Reactant Info Product Info
Metabolic Enzyme NADPH-dependent carbonyl reductase 3 (CBR3) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000786 Deutetrabenazine D6alpha-dihydrotetrabenazine Unclear Deutetrabenazine [1]
MR000788 Deutetrabenazine Deutetrabenazine metabolite M4 Oxidation - Hydroxylation Deutetrabenazine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000782 Cis (2,3)-Dihydro Tetrabenazine-d6 D3-10-O-Desmethyl-beta-Htbz Oxidation - Demethylation Deutetrabenazine [1]
MR000781 Cis (2,3)-Dihydro Tetrabenazine-d6 D3-9-O-Desmethyl-beta-Htbz Oxidation - Demethylation Deutetrabenazine [1]
MR000783 Cis (2,3)-Dihydro Tetrabenazine-d6 Deutetrabenazine metabolite M1 Unclear Deutetrabenazine [1]
References
1 Pharmacokinetic and Metabolic Profile of Deutetrabenazine (TEV-50717) Compared With Tetrabenazine in Healthy Volunteers Clin Transl Sci. 2020 Jul;13(4):707-717. doi: 10.1111/cts.12754.

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