Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000783)
Formula
SVG example
Reactant Cis (2,3)-Dihydro Tetrabenazine-d6 Product Deutetrabenazine metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000787 Deutetrabenazine Cis (2,3)-Dihydro Tetrabenazine-d6 Unclear Deutetrabenazine [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000782 Cis (2,3)-Dihydro Tetrabenazine-d6 D3-10-O-Desmethyl-beta-Htbz Oxidation - Demethylation Deutetrabenazine [1]
MR000781 Cis (2,3)-Dihydro Tetrabenazine-d6 D3-9-O-Desmethyl-beta-Htbz Oxidation - Demethylation Deutetrabenazine [1]
References
1 Pharmacokinetic and Metabolic Profile of Deutetrabenazine (TEV-50717) Compared With Tetrabenazine in Healthy Volunteers Clin Transl Sci. 2020 Jul;13(4):707-717. doi: 10.1111/cts.12754.

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