Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000781)
Formula
SVG example
Demethylation
Reactant Cis (2,3)-Dihydro Tetrabenazine-d6 Product D3-9-O-Desmethyl-beta-Htbz
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000787 Deutetrabenazine Cis (2,3)-Dihydro Tetrabenazine-d6 Unclear Deutetrabenazine [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000782 Cis (2,3)-Dihydro Tetrabenazine-d6 D3-10-O-Desmethyl-beta-Htbz Oxidation - Demethylation Deutetrabenazine [1]
MR000783 Cis (2,3)-Dihydro Tetrabenazine-d6 Deutetrabenazine metabolite M1 Unclear Deutetrabenazine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000784 D3-9-O-Desmethyl-beta-Htbz Sulfate of O\desmethyl beta\HTBZ Conjugation - Sulfation Deutetrabenazine [1]
References
1 Pharmacokinetic and Metabolic Profile of Deutetrabenazine (TEV-50717) Compared With Tetrabenazine in Healthy Volunteers Clin Transl Sci. 2020 Jul;13(4):707-717. doi: 10.1111/cts.12754.

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