Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000790)
Formula Reactant Dexamethasone sodium phosphate Product 11-dehydrodexamethasone
Reactant Info Product Info
Metabolic Enzyme Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000791 Dexamethasone sodium phosphate 6alpha-hydroxydexamethasone Oxidation - Hydroxylation Dexamethasone sodium phosphate [1]
MR000792 Dexamethasone sodium phosphate 6beta-hydroxydexamethasone Oxidation - Hydroxylation Dexamethasone sodium phosphate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006143 NOVA-63035 11-dehydrodexamethasone Reduction - Reduction NOVA-63035 [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000789 11-dehydrodexamethasone Dexamethasone Unclear Dexamethasone sodium phosphate [2], [3]
MR006144 11-dehydrodexamethasone Dexamethasone Reduction - Reduction NOVA-63035 [2]
References
1 Dexamethasone metabolism in vitro: species differences J Steroid Biochem Mol Biol. 1997 Jul;62(4):345-52. doi: 10.1016/s0960-0760(97)00038-1.
2 Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction J Clin Endocrinol Metab. 1997 May;82(5):1598-602. doi: 10.1210/jcem.82.5.3936.
3 Metabolism of synthetic corticosteroids by 11 beta-hydroxysteroid-dehydrogenases in man Steroids. 1998 May-Jun;63(5-6):271-7. doi: 10.1016/s0039-128x(98)00039-7.

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