Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000791)
Formula
SVG example
Hydroxylation
Reactant Dexamethasone sodium phosphate Product 6alpha-hydroxydexamethasone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000790 Dexamethasone sodium phosphate 11-dehydrodexamethasone Reduction - Reduction Dexamethasone sodium phosphate [1], [2]
MR000792 Dexamethasone sodium phosphate 6beta-hydroxydexamethasone Oxidation - Hydroxylation Dexamethasone sodium phosphate [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006145 NOVA-63035 6alpha-Hydroxydexamethasone Oxidation - Aliphatic hydroxylation NOVA-63035 [4]
References
1 Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction J Clin Endocrinol Metab. 1997 May;82(5):1598-602. doi: 10.1210/jcem.82.5.3936.
2 Metabolism of synthetic corticosteroids by 11 beta-hydroxysteroid-dehydrogenases in man Steroids. 1998 May-Jun;63(5-6):271-7. doi: 10.1016/s0039-128x(98)00039-7.
3 Dexamethasone metabolism in vitro: species differences J Steroid Biochem Mol Biol. 1997 Jul;62(4):345-52. doi: 10.1016/s0960-0760(97)00038-1.
4 Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation

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