Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000806)
Formula
SVG example
Hydroxylation
Reactant Dexmethylphenidate Product p-hydroxy-methylphenidate
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000807 Dexmethylphenidate 6-oxo-methylphenidate Oxidation - Oxidation Dexmethylphenidate [1]
MR000805 Dexmethylphenidate Ritalinic acid Other reaction - Deesterification Dexmethylphenidate [2]
References
1 Pharmacokinetics and clinical effectiveness of methylphenidate Clin Pharmacokinet. 1999 Dec;37(6):457-70. doi: 10.2165/00003088-199937060-00002.
2 Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. J Pharmacol Exp Ther. 2004 Aug;310(2):469-76.

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