General Information of This Metabolic Reaction (MR) (ID:
MR000805) |
Formula |
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Reactant |
Dexmethylphenidate |
Product |
Ritalinic acid |
Reactant Info
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Product Info
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Metabolic Enzyme
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Carboxylesterase (CES1A1a)
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DME Info
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Metabolic Type
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Other reaction
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Deesterification
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Other MR(s) Related to The Reactant of This MR |
Other MR(s) That Metabolize The Reactant of This MR
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Other MR(s) Related to The Product of This MR |
Other MR(s) That Produce The Product of This MR
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References |
1 |
Pharmacokinetics and clinical effectiveness of methylphenidate Clin Pharmacokinet. 1999 Dec;37(6):457-70. doi: 10.2165/00003088-199937060-00002.
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2 |
Metabolism of methylphenidate in dog and rat
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3 |
Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. J Pharmacol Exp Ther. 2004 Aug;310(2):469-76.
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