Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000849)
Formula
SVG example
Cleavage
Reactant Digoxigenin-monodigitoxoside Product Digoxigenin
Reactant Info Product Info
Metabolic Type Oxidation - Cleavage
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000848 Digoxigenin-bisdigitoxoside Digoxigenin-monodigitoxoside Oxidation - Cleavage Digoxin [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000850 Digoxigenin-monodigitoxoside DG1 glucuronidation Conjugation - Glucuronidation Digoxin [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000851 Digoxigenin Digitoxigenin sulfated cardioinactive compound Conjugation - Conjugation Digoxin [3]
References
1 Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A Xenobiotica. 1999 Feb;29(2):171-85. doi: 10.1080/004982599238722.
2 Metabolism of digoxin, digoxigenin digitoxosides and digoxigenin in human hepatocytes and liver microsomes Fundam Clin Pharmacol. 1991;5(7):567-82. doi: 10.1111/j.1472-8206.1991.tb00746.x.
3 American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 2511

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