Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000848)
Formula
SVG example
Cleavage
Reactant Digoxigenin-bisdigitoxoside Product Digoxigenin-monodigitoxoside
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Cleavage
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000855 Digoxin Digoxigenin-bisdigitoxoside Oxidation - Cleavage Digoxin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000850 Digoxigenin-monodigitoxoside DG1 glucuronidation Conjugation - Glucuronidation Digoxin [2]
MR000849 Digoxigenin-monodigitoxoside Digoxigenin Oxidation - Cleavage Digoxin [3]
References
1 Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A Xenobiotica. 1999 Feb;29(2):171-85. doi: 10.1080/004982599238722.
2 Metabolism of digoxin, digoxigenin digitoxosides and digoxigenin in human hepatocytes and liver microsomes Fundam Clin Pharmacol. 1991;5(7):567-82. doi: 10.1111/j.1472-8206.1991.tb00746.x.
3 American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 2511

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