Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000873)
Formula
SVG example
Oxidation
Reactant N,N-didesmethyldiphenhydramine Product Diphenylmethoxyacetic acid
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000872 N-desmethyldiphenhydramine N,N-didesmethyldiphenhydramine Oxidation - N-Demethylation Diphenhydramine [1], [2], [3]
MR011194 N-Desmethyldiphenhydramine N,N-Didesmethyldiphenhydramine Unclear - Unclear Dimenhydrinate [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000874 N,N-didesmethyldiphenhydramine N-acetyl-N-desmethyldiphenhydramine Conjugation - Acetylation Diphenhydramine [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000875 Diphenylmethoxyacetic acid . Conjugation - Conjugation Diphenhydramine [4]
References
1 Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation. Drug Metab Dispos. 2007 Jan;35(1):72-8.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Bioconcentration, metabolism and effects of diphenhydramine on behavioral and biochemical markers in crucian carp (Carassius auratus) Sci Total Environ. 2016 Feb 15;544:400-9. doi: 10.1016/j.scitotenv.2015.11.132.
4 American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 2511

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