Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000872)
Formula
CYP2D6 ...
SVG example
N-Demethylation
Reactant N-desmethyldiphenhydramine Product N,N-didesmethyldiphenhydramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000876 Diphenhydramine N-desmethyldiphenhydramine Oxidation - N-Demethylation Diphenhydramine [1], [2], [3], [4]
MR011193 Diphenhydramine N-Desmethyldiphenhydramine Unclear - Unclear Dimenhydrinate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000873 N,N-didesmethyldiphenhydramine Diphenylmethoxyacetic acid Oxidation - Oxidation Diphenhydramine [2], [3]
MR000874 N,N-didesmethyldiphenhydramine N-acetyl-N-desmethyldiphenhydramine Conjugation - Acetylation Diphenhydramine [2], [3]
MR011195 N,N-Didesmethyldiphenhydramine Diphenylmethoxyacetic acid Unclear - Unclear Dimenhydrinate [2]
References
1 Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation. Drug Metab Dispos. 2007 Jan;35(1):72-8.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Bioconcentration, metabolism and effects of diphenhydramine on behavioral and biochemical markers in crucian carp (Carassius auratus) Sci Total Environ. 2016 Feb 15;544:400-9. doi: 10.1016/j.scitotenv.2015.11.132.
4 Non-invasive skin sampling detects systemically administered drugs in humans. PLoS One. 2022 Jul 26;17(7):e0271794. doi: 10.1371/journal.pone.0271794.

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