Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000877)
Formula
UGT
SVG example
Glucuronidation
Reactant Diphenhydramine Product Diphenhydramine N-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000878 Diphenhydramine N-acetyldidesmethyldiphenhydramine Unclear Diphenhydramine [1]
MR000876 Diphenhydramine N-desmethyldiphenhydramine Oxidation - N-Demethylation Diphenhydramine [2], [3], [4], [5]
MR011193 Diphenhydramine N-Desmethyldiphenhydramine Unclear - Unclear Dimenhydrinate [3]
References
1 Metabolism of the ethanolamine-type antihistamine diphenhydramine (Benadryl) by the fungus Cunninghamella elegans Appl Microbiol Biotechnol. 2000 Mar;53(3):310-5. doi: 10.1007/s002530050026.
2 Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation. Drug Metab Dispos. 2007 Jan;35(1):72-8.
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
4 Bioconcentration, metabolism and effects of diphenhydramine on behavioral and biochemical markers in crucian carp (Carassius auratus) Sci Total Environ. 2016 Feb 15;544:400-9. doi: 10.1016/j.scitotenv.2015.11.132.
5 Non-invasive skin sampling detects systemically administered drugs in humans. PLoS One. 2022 Jul 26;17(7):e0271794. doi: 10.1371/journal.pone.0271794.

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