Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000878)
Formula Reactant Diphenhydramine Product N-acetyldidesmethyldiphenhydramine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000877 Diphenhydramine Diphenhydramine N-glucuronide Conjugation - Glucuronidation Diphenhydramine [1], [2]
MR000876 Diphenhydramine N-desmethyldiphenhydramine Oxidation - N-Demethylation Diphenhydramine [3], [1], [4], [2]
MR011196 Diphenhydramine Diphenhydramine N-glucuronide Unclear - Unclear Dimenhydrinate [1]
MR011193 Diphenhydramine N-Desmethyldiphenhydramine Unclear - Unclear Dimenhydrinate [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Non-invasive skin sampling detects systemically administered drugs in humans. PLoS One. 2022 Jul 26;17(7):e0271794. doi: 10.1371/journal.pone.0271794.
3 Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation. Drug Metab Dispos. 2007 Jan;35(1):72-8.
4 Bioconcentration, metabolism and effects of diphenhydramine on behavioral and biochemical markers in crucian carp (Carassius auratus) Sci Total Environ. 2016 Feb 15;544:400-9. doi: 10.1016/j.scitotenv.2015.11.132.

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