Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000892)
Formula
SVG example
N-Dealkylation
Reactant Dofetilide Product N-desmethyl dofetllfde
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000894 Dofetilide Dofetilide metabolite M1 Hydrolysis - Hydrolysis Dofetilide [1]
MR000895 Dofetilide Dofetilide metabolite M2 Hydrolysis - Hydrolysis Dofetilide [1]
MR000893 Dofetilide Dofetilide N-oxide Oxidation - N-Oxidation Dofetilide [1]
References
1 Dofetilide, a novel class III antiarrhythmic agent J Cardiovasc Pharmacol. 1992;20 Suppl 2:S96-105.

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