Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000930)
Formula
UGT1A9 ...
SVG example
Reactant Ertugliflozin metabolite M2 Product Ertugliflozin metabolite M5a
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000932 Ertugliflozin Ertugliflozin metabolite M2 Conjugation - Glucuronidation Ertugliflozin [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000931 Ertugliflozin metabolite M2 Ertugliflozin metabolite M5c Unclear Ertugliflozin [2]
References
1 In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes Drug Metab Dispos. 2020 Dec;48(12):1350-1363. doi: 10.1124/dmd.120.000171.
2 Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects Drug Metab Dispos. 2013 Feb;41(2):445-56. doi: 10.1124/dmd.112.049551.

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