Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000932)
Formula
CYP3A4 ...
SVG example
Glucuronidation
Reactant Ertugliflozin Product Ertugliflozin metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000933 Ertugliflozin Ertugliflozin metabolite M1a Oxidation - Hydroxylation Ertugliflozin [1], [2]
MR000934 Ertugliflozin Ertugliflozin metabolite M1b Oxidation - Hydroxylation Ertugliflozin [1], [2]
MR000935 Ertugliflozin Ertugliflozin metabolite M3 Conjugation - Glucuronidation Ertugliflozin [1], [2]
MR000936 Ertugliflozin Ertugliflozin metabolite M4a Conjugation - Glucuronidation Ertugliflozin [2]
MR000937 Ertugliflozin Ertugliflozin metabolite M4b Conjugation - Glucuronidation Ertugliflozin [2]
MR000938 Ertugliflozin Ertugliflozin metabolite M4c Conjugation - Glucuronidation Ertugliflozin [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000930 Ertugliflozin metabolite M2 Ertugliflozin metabolite M5a Unclear Ertugliflozin [2]
MR000931 Ertugliflozin metabolite M2 Ertugliflozin metabolite M5c Unclear Ertugliflozin [2]
References
1 In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes Drug Metab Dispos. 2020 Dec;48(12):1350-1363. doi: 10.1124/dmd.120.000171.
2 Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects Drug Metab Dispos. 2013 Feb;41(2):445-56. doi: 10.1124/dmd.112.049551.

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