Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000943)
Formula Reactant Escitalopram Product Escitalopram propionic acid
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Monoamine oxidase (MAO) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000942 Escitalopram S-desmethylcitalopram Oxidation - N-Demethylation Escitalopram [1], [2]
References
1 PharmGKB summary: citalopram pharmacokinetics pathway. Pharmacogenet Genomics. 2011 Nov;21(11):769-72.
2 Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram Drug Metab Dispos. 2001 Aug;29(8):1102-9.

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