General Information of DME (ID: DMEN059)
DME Name	Monoamine oxidase (MAO), .
Gene Name	MAO
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME

Full List of Drug(s) Metabolized by This DME
Drugs Approved by FDA			Click to Show/Hide the Full List of Drugs:          3 Drugs
Dopamine hydrochloride	Drug Info	Approved	Parkinsonism	ICD11: 8A00	[1]
Procarbazine	Drug Info	Approved	Anaplastic large cell lymphoma	ICD11: 2A90	[2]
Docarpamine	Drug Info	Approved	Hypertension	ICD11: BA00-BA04	[3]

Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF MR008915 Dopamine 3,4-dihydroxyphenylacetic acid Unclear - Unclear Docarpamine [3] MR006630 3-MT MHPA Unclear - Unclear Dopamine hydrochloride [1] MR006626 Dopamine hydrochloride DHPA Unclear - Unclear Dopamine hydrochloride [1] MR000943 Escitalopram Escitalopram propionic acid Unclear - Unclear Escitalopram [4] MR001492 3-Methoxytyramine 3-methoxy-4-hydroxyacetaldehyde Oxidation - Oxidative Deamination Levodopa [5] MR001486 Dopamine 3,4-Dihydroxyphenylacetaldehyde (DOPAL) Oxidation - Oxidative Deamination Levodopa [5] ⏷ Show the Full List of 6 MR(s)

References
1	Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain
2	In vitro and in vivo evidence for the formation of methyl radical from procarbazine: a spin-trapping study. Carcinogenesis. 1992 May;13(5):799-805.
3	Metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) and dopamine after oral administration to rats and dogs
4	Identification of a novel CYP2C19-mediated metabolic pathway of S-citalopram in vitro Drug Metab Dispos. 2009 Dec;37(12):2340-8. doi: 10.1124/dmd.109.029355.
5	DrugBank(Pharmacology-Metabolism)Levodopa

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