Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000942)
Formula
CYP3A4 ...
SVG example
N-Demethylation
Reactant Escitalopram Product S-desmethylcitalopram
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000943 Escitalopram Escitalopram propionic acid Unclear Escitalopram [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000941 S-desmethylcitalopram S-didesmethylcitalopram Oxidation - N-Demethylation Escitalopram [2]
References
1 Identification of a novel CYP2C19-mediated metabolic pathway of S-citalopram in vitro Drug Metab Dispos. 2009 Dec;37(12):2340-8. doi: 10.1124/dmd.109.029355.
2 PharmGKB summary: citalopram pharmacokinetics pathway. Pharmacogenet Genomics. 2011 Nov;21(11):769-72.

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