Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000985)
Formula
SVG example
Hydroxylation
Reactant Etravirine metabolite M3 Product Etravirine metabolite M4
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000989 Etravirine Etravirine metabolite M3 Oxidation - Hydroxylation Etravirine [1], [2]
References
1 Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism. Drug Metab Dispos. 2012 Apr;40(4):803-14.
2 Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74.

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