Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000989)
Formula
SVG example
Hydroxylation
Reactant Etravirine Product Etravirine metabolite M3
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000990 Etravirine Etravirine metabolite M1 Oxidation - Hydroxylation Etravirine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000985 Etravirine metabolite M3 Etravirine metabolite M4 Oxidation - Hydroxylation Etravirine [2]
References
1 Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism. Drug Metab Dispos. 2012 Apr;40(4):803-14.
2 Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74.

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