Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000986)
Formula
SVG example
Hydroxylation
Reactant Etravirine metabolite M1 Product Etravirine metabolite M5/6
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000990 Etravirine Etravirine metabolite M1 Oxidation - Hydroxylation Etravirine [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000987 Etravirine metabolite M1 Etravirine metabolite M6/5 Oxidation - Hydroxylation Etravirine [2]
MR000988 Etravirine metabolite M1 Etravirine metabolite M7 Conjugation - Glucuronidation Etravirine [2]
References
1 Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism. Drug Metab Dispos. 2012 Apr;40(4):803-14.
2 Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74.

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