Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000988)
Formula Reactant Etravirine metabolite M1 Product Etravirine metabolite M7
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000990 Etravirine Etravirine metabolite M1 Oxidation - Hydroxylation Etravirine [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000986 Etravirine metabolite M1 Etravirine metabolite M5/6 Oxidation - Hydroxylation Etravirine [2]
MR000987 Etravirine metabolite M1 Etravirine metabolite M6/5 Oxidation - Hydroxylation Etravirine [2]
References
1 Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism. Drug Metab Dispos. 2012 Apr;40(4):803-14.
2 Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74.

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