Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000998)
Formula Reactant Everolimus Product 39-O-desmethyl everolimus
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000997 Everolimus 24-hydroxy Everolimus Oxidation - Hydroxylation Everolimus [1]
MR000996 Everolimus 25-hydroxy Everolimus Oxidation - Hydroxylation Everolimus [1]
MR000995 Everolimus 46-hydroxy Everolimus Oxidation - Hydroxylation Everolimus [1]
References
1 Identification of everolimus metabolite patterns in trough blood samples of kidney transplant patients Ther Drug Monit. 2007 Oct;29(5):592-9. doi: 10.1097/FTD.0b013e3181570830.

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