Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001000)
Formula Reactant Exemestane Product 6-hydroxymethylandrosta-1,4,6-triene-3,17-dione
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 3A (CYP3A) DME Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001002 Exemestane . Oxidation - Oxidation Exemestane [1], [2]
MR001001 Exemestane 17beta-DHE conjugation with glucuronic acid Conjugation - Conjugation Exemestane [1], [3]
MR000999 Exemestane 17beta-dihydroexemestane Reduction - Reduction Exemestane [1], [3], [4]
References
1 In vitro metabolism of exemestane by hepatic cytochrome P450s: impact of nonsynonymous polymorphisms on formation of the active metabolite 17beta-dihydroexemestane. Pharmacol Res Perspect. 2017 Apr 27;5(3):e00314.
2 LABEL:EXEMESTANE tablet
3 Inhibition of the aromatase enzyme by exemestane cysteine conjugates. Mol Pharmacol. 2022 Aug 11;102(5):216-22. doi: 10.1124/molpharm.122.000545.
4 Influence of Glutathione-S-Transferase A1*B Allele on the Metabolism of the Aromatase Inhibitor, Exemestane, in Human Liver Cytosols and in Patients Treated With Exemestane. J Pharmacol Exp Ther. 2022 Sep;382(3):327-334. doi: 10.1124/jpet.122.001232.

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