Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000999)
Formula
CYP1A2 ...
SVG example
Reduction
Reactant Exemestane Product 17beta-dihydroexemestane
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Lauric acid omega-hydroxylase (CYP4A11) DME Info
Aldo-keto reductases (AKR) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001002 Exemestane . Oxidation - Oxidation Exemestane [1], [2]
MR001001 Exemestane 17beta-DHE conjugation with glucuronic acid Conjugation - Conjugation Exemestane [1], [3]
MR001000 Exemestane 6-hydroxymethylandrosta-1,4,6-triene-3,17-dione Oxidation - Deamination Exemestane [1]
References
1 In vitro metabolism of exemestane by hepatic cytochrome P450s: impact of nonsynonymous polymorphisms on formation of the active metabolite 17beta-dihydroexemestane. Pharmacol Res Perspect. 2017 Apr 27;5(3):e00314.
2 LABEL:EXEMESTANE tablet
3 Inhibition of the aromatase enzyme by exemestane cysteine conjugates. Mol Pharmacol. 2022 Aug 11;102(5):216-22. doi: 10.1124/molpharm.122.000545.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.