Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001009)
Formula Reactant Ezetimibe Product Benzylic glucuronide SCH 488128
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001008 Ezetimibe Ezetimibe-glucuronide Conjugation - Glucuronidation Ezetimibe [1], [2], [3], [4]
MR001007 Ezetimibe SCH 57871 Conjugation - Glucuronidation Ezetimibe [1]
References
1 Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94.
2 Bioequivalence Study of Ezetimibe Tablets After a Single Oral Dose of 10?mg in Healthy Japanese Subjects Under Fasting Conditions. Clin Pharmacol Drug Dev. 2023 Apr 6. doi: 10.1002/cpdd.1245.
3 Pharmacokinetics and bioequivalence of Ezetimibe tablet versus Ezetrol?:an open-label, randomized, two-sequence crossover study in healthy Chinese subjects. BMC Pharmacol Toxicol. 2023 Feb 3;24(1):7. doi: 10.1186/s40360-023-00649-y.
4 Investigation of the discriminatory ability of analytes for the bioequivalence assessment of ezetimibe: Parent drug, metabolite, total form, and combination of parent drug and total form. Eur J Pharm Sci. 2022 Jul 1;174:106192. doi: 10.1016/j.ejps.2022.106192.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.