Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001027)
Formula
PE
SVG example
Hydrolysis
Reactant Fesoterodine Product Fesoterodine 5-hydroxymethyl tolterodine
Reactant Info Product Info
Metabolic Enzyme Plasma esterase (PE) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001028 Fesoterodine Fesoterodine carboxy-N-desisopropyl metabolite Unclear Fesoterodine [1], [2]
MR001029 Fesoterodine Fesoterodine N-desisopropyl metabolite Unclear Fesoterodine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006782 Tolterodine tartrate 5-Hydroxymethyl tolterodine Oxidation - Methyl-hydroxylation Tolterodine tartrate [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006783 5-Hydroxymethyl tolterodine 5-Carboxylic acid tolterodine Unclear Tolterodine tartrate [3]
MR001026 Fesoterodine 5-hydroxymethyl tolterodine Fesoterodine carboxy metabolite Unclear Fesoterodine [1], [2]
MR006784 5-Hydroxymethyl tolterodine N-Dealkylated 5-hydroxymethyl tolterodine Unclear Tolterodine tartrate [3]
References
1 Physiologically Based Pharmacokinetic Modeling Suggests Limited Drug-Drug Interaction for Fesoterodine When Coadministered With Mirabegron J Clin Pharmacol. 2019 Nov;59(11):1505-1518. doi: 10.1002/jcph.1438.
2 LABEL:FESOTERODINE FUMARATE tablet, extended release
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.