Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006782)
Formula
SVG example
Methyl-hydroxylation
Reactant Tolterodine tartrate Product 5-Hydroxymethyl tolterodine
Reactant Info Product Info
Metabolic Type Oxidation - Methyl-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006780 Tolterodine tartrate N-Dealkylated tolterodine Oxidation - N-dealkylation Tolterodine tartrate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001027 Fesoterodine Fesoterodine 5-hydroxymethyl tolterodine Hydrolysis - Hydrolysis Fesoterodine [2], [3], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006783 5-Hydroxymethyl tolterodine 5-Carboxylic acid tolterodine Unclear Tolterodine tartrate [1]
MR001026 Fesoterodine 5-hydroxymethyl tolterodine Fesoterodine carboxy metabolite Unclear Fesoterodine [2], [5]
MR006784 5-Hydroxymethyl tolterodine N-Dealkylated 5-hydroxymethyl tolterodine Unclear Tolterodine tartrate [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Physiologically Based Pharmacokinetic Modeling Suggests Limited Drug-Drug Interaction for Fesoterodine When Coadministered With Mirabegron J Clin Pharmacol. 2019 Nov;59(11):1505-1518. doi: 10.1002/jcph.1438.
3 Population Pharmacokinetic and Pharmacodynamic Modeling of Fesoterodine in Pediatric Patients?with Neurogenic Detrusor Overactivity. Eur J Drug Metab Pharmacokinet. 2023 May;48(3):257-269. doi: 10.1007/s13318-023-00818-8.
4 Fesoterodine treatment of pediatric patients with neurogenic detrusor overactivity: A 24-week, randomized, open-label, phase 3 study. J Pediatr Urol. 2023 Apr;19(2):175.e1-175.e10. doi: 10.1016/j.jpurol.2022.11.020.
5 LABEL:FESOTERODINE FUMARATE tablet, extended release

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