Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001052)
Formula
CYP2D6 ...
SVG example
Meta-O-Dealkylation
Reactant Flecainide acetate Product Meta-O-dealkylated lactam
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - Meta-O-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001051 Flecainide acetate Meta-O-dealkylated flecainide Oxidation - Meta-O-Dealkylation Flecainide acetate [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001050 Meta-O-dealkylated lactam . Unclear Flecainide acetate [3]
References
1 Effects of CYP2D6 genotypes on age-related change of flecainide metabolism: involvement of CYP1A2-mediated metabolism. Br J Clin Pharmacol. 2009 Jul;68(1):89-96.
2 Flecainide: current status and perspectives in arrhythmia management. World J Cardiol. 2015 Feb 26;7(2):76-85.
3 Metabolism of flecainide Am J Cardiol. 1984 Feb 27;53(5):41B-51B. doi: 10.1016/0002-9149(84)90501-0.

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