Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001083)
Formula
SVG example
Reduction
Reactant Folic acid Product Dihydrofolate
Reactant Info Product Info
Metabolic Enzyme Dihydrofolate reductase (DHFR) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001084 Folic acid Tetrahydrofolic acid Reduction - Reduction Folic acid [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005334 Deoxy-UMP 7,8-dihydrofolate (H2folate) Unclear Deoxy-UMP [2]
MR001536 Dihydropteroate Dihydrofolate Unclear L-glutamine [3]
References
1 DrugBank(Pharmacology-Metabolism)Folic acid
2 Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase. Chem Biol. 1995 Sep;2(9):609-14.
3 Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site. Biochemistry. 2008 Feb 26;47(8):2388-96.

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