Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001087)
Formula
SVG example
Reactant R406 Product R529
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001092 Fostamatinib R406 Unclear Fostamatinib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001088 R406 R406 N-glucuronide metabolite Conjugation - N-Glucuronidation Fostamatinib [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001089 R529 3,5 benzene diol metabolite of R406 Oxidation - Oxidation Fostamatinib [3]
MR001091 R529 R529 O-glucuronide metabolite Conjugation - O-Glucuronidation Fostamatinib [2]
MR001090 R529 R529 Sulfate-conjugate metabolite Conjugation - Sulfation Fostamatinib [2]
References
1 Metabolism of fostamatinib, the oral methylene phosphate prodrug of the spleen tyrosine kinase inhibitor R406 in humans: contribution of hepatic and gut bacterial processes to the overall biotransformation Drug Metab Dispos. 2010 Jul;38(7):1166-76. doi: 10.1124/dmd.110.032151.
2 DrugBank(Pharmacology-Metabolism)Fostamatinib
3 Clinical Pharmacokinetics and Pharmacodynamics of Fostamatinib and Its Active Moiety R406 Clin Pharmacokinet. 2022 Jul;61(7):955-972. doi: 10.1007/s40262-022-01135-0.

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