Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001111)
Formula
SVG example
N-Oxidation
Reactant Galantamine hydrobromide Product Galantamine N-oxide metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001112 Galantamine hydrobromide Galantamine glucuronide metabolite Conjugation - Glucuronidation Galantamine hydrobromide [1]
MR001109 Galantamine hydrobromide Galantaminone Oxidation - Oxidation Galantamine hydrobromide [1]
MR001113 Galantamine hydrobromide N-desmethyl-galantamine Unclear Galantamine hydrobromide [1]
MR001110 Galantamine hydrobromide O-desmethyl-galantamine Oxidation - O-Demethylation Galantamine hydrobromide [1], [2]
MR001114 Galantamine hydrobromide Sulfate conjugate of galantamine Conjugation - Sulfation Galantamine hydrobromide [1]
References
1 The metabolism and excretion of galantamine in rats, dogs, and humans Drug Metab Dispos. 2002 May;30(5):553-63. doi: 10.1124/dmd.30.5.553.
2 Clinical pharmacokinetics of galantamine. Clin Pharmacokinet. 2003;42(15):1383-92.

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