Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001110)
Formula
SVG example
O-Demethylation
Reactant Galantamine hydrobromide Product O-desmethyl-galantamine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001112 Galantamine hydrobromide Galantamine glucuronide metabolite Conjugation - Glucuronidation Galantamine hydrobromide [1]
MR001111 Galantamine hydrobromide Galantamine N-oxide metabolite Oxidation - N-Oxidation Galantamine hydrobromide [1], [2]
MR001109 Galantamine hydrobromide Galantaminone Oxidation - Oxidation Galantamine hydrobromide [1]
MR001113 Galantamine hydrobromide N-desmethyl-galantamine Unclear Galantamine hydrobromide [1]
MR001114 Galantamine hydrobromide Sulfate conjugate of galantamine Conjugation - Sulfation Galantamine hydrobromide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001108 O-desmethyl-galantamine O-desmethyl-galantamine glucuronide metabolite Conjugation - Glucuronidation Galantamine hydrobromide [3]
MR001107 O-desmethyl-galantamine Sulfate conjugate of O-desmethyl-galantamine Conjugation - Sulfation Galantamine hydrobromide [3]
References
1 The metabolism and excretion of galantamine in rats, dogs, and humans Drug Metab Dispos. 2002 May;30(5):553-63. doi: 10.1124/dmd.30.5.553.
2 Clinical pharmacokinetics of galantamine. Clin Pharmacokinet. 2003;42(15):1383-92.
3 DrugBank(Pharmacology-Metabolism)Galantamine hydrobromide

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