Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001116)
Formula
SVG example
O-Demethylation
Reactant Gefitinib Product Desmethyl-gefitinib M523595
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001115 Gefitinib Metabolism of the N-propoxymorpholino-group Unclear Gefitinib [1]
MR001117 Gefitinib Oxidative defluorination of the halogenated phenyl group Oxidation - Oxidative Defluorination Gefitinib [1]
References
1 Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.

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