Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012328)
Formula Reactant Gemcitabine Product DFdC
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001122 Gemcitabine 2',2'-Difluorodeoxyuridine Oxidation - Deamination Gemcitabine [1], [2]
MR001121 Gemcitabine Gemcitabine Monophosphate Other reaction - Phosphorylation Gemcitabine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012329 DFdC DFdCMP Unclear - Unclear CO-101 [3]
MR012333 DFdC DFdU Unclear - Unclear CO-101 [3]
References
1 Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective Cancer Chemother Pharmacol. 2016 Jul;78(1):1-12. doi: 10.1007/s00280-016-3003-0.
2 Gemcitabine. A review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer Drugs. 1997 Sep;54(3):447-72. doi: 10.2165/00003495-199754030-00009.
3 Phase I study of oral CP-4126, a gemcitabine derivative, in patients with advanced solid tumors

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