Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001182)
Formula
SVG example
Oxidation
Reactant Indapamide Product Indapamide metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001184 Indapamide Indapamide epoxide intermediate Oxidation - Oxidation Indapamide [1]
MR001183 Indapamide Indapamide metabolite M5 Oxidation - Oxidation Indapamide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001176 Indapamide metabolite M1 Indapamide metabolite M3 Oxidation - Oxidation Indapamide [1]
References
1 Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions. Drug Metab Dispos. 2009 Mar;37(3):672-84.

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