Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001184)
Formula Reactant Indapamide Product Indapamide epoxide intermediate
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001182 Indapamide Indapamide metabolite M1 Oxidation - Oxidation Indapamide [1], [2]
MR001183 Indapamide Indapamide metabolite M5 Oxidation - Oxidation Indapamide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001180 Indapamide epoxide intermediate Indapamide glutathione conjugate M7 Conjugation - Glutathione Conjugation Indapamide [1]
MR001181 Indapamide epoxide intermediate Indapamide metabolite M6 Oxidation - Dihydroxylation Indapamide [1]
References
1 Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions. Drug Metab Dispos. 2009 Mar;37(3):672-84.
2 Vasorelaxant actions of 5-OH-indapamide, a major metabolite of indapamide: comparison with indapamide, hydrochlorothiazide and cicletanine Eur J Pharmacol. 1994 Apr 21;256(2):185-91. doi: 10.1016/0014-2999(94)90244-5.

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