Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001185)
Formula
SVG example
N-Depyridomethylation
Reactant Indinavir sulfate metabolite M4a Product Indinavir sulfate metabolite M6
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Depyridomethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001191 Indinavir sulfate Indinavir sulfate metabolite M4a Oxidation - Oxidation Indinavir sulfate [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001186 Indinavir sulfate metabolite M4a Indinavir sulfate metabolite M2 Oxidation - Hydroxylation Indinavir sulfate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001192 Indinavir sulfate Indinavir sulfate metabolite M6 Oxidation - N-Depyridomethylation Indinavir sulfate [1], [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001187 Indinavir sulfate metabolite M6 Indinavir sulfate metabolite M5 Oxidation - Hydroxylation Indinavir sulfate [1]
References
1 Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A. Biochem Pharmacol. 1997 Apr 25;53(8):1187-95.
2 Involvement of CYP3A4 and MDR1 in altered metabolism and transport of indinavir in 1,25(OH)(2)D(3)-treated Caco-2 cells. Eur J Pharm Sci. 2023 Apr 1;183:106396. doi: 10.1016/j.ejps.2023.106396.

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