Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001186)
Formula
SVG example
Hydroxylation
Reactant Indinavir sulfate metabolite M4a Product Indinavir sulfate metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001191 Indinavir sulfate Indinavir sulfate metabolite M4a Oxidation - Oxidation Indinavir sulfate [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001185 Indinavir sulfate metabolite M4a Indinavir sulfate metabolite M6 Oxidation - N-Depyridomethylation Indinavir sulfate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001188 Indinavir sulfate metabolite M2 Indinavir sulfate metabolite M5 Oxidation - N-Depyridomethylation Indinavir sulfate [1]
References
1 Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A. Biochem Pharmacol. 1997 Apr 25;53(8):1187-95.

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