Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001188)
Formula
SVG example
N-Depyridomethylation
Reactant Indinavir sulfate metabolite M2 Product Indinavir sulfate metabolite M5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Depyridomethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001186 Indinavir sulfate metabolite M4a Indinavir sulfate metabolite M2 Oxidation - Hydroxylation Indinavir sulfate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001189 Indinavir sulfate metabolite M3 Indinavir sulfate metabolite M5 Oxidation - N-Depyridomethylation Indinavir sulfate [1]
MR001187 Indinavir sulfate metabolite M6 Indinavir sulfate metabolite M5 Oxidation - Hydroxylation Indinavir sulfate [1]
References
1 Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A. Biochem Pharmacol. 1997 Apr 25;53(8):1187-95.

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