Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001198)
Formula
SVG example
O-Demethylation
Reactant Deacyl indomethacin Product O-Desmethyl-N-deschlorobenzoyl indomethacin
Reactant Info Product Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000039 Acemetacin Deacyl indomethacin Other reaction - N-Dehydroxylation; Hydrolysis Acemetacin [1]
MR001201 Indomethacin Deacyl indomethacin Unclear Indomethacin [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000034 Deacyl indomethacin Deacyl indomethacin glucuronide Unclear Acemetacin [1]
MR001199 Deacyl indomethacin Deacyl indomethacin glucuronide Conjugation - Glucuronidation Indomethacin [2]
References
1 DrugBank(Pharmacology-Metabolism)Acemetacin
2 Comparative in vitro metabolism of phospho-tyrosol-indomethacin by mice, rats and humans Biochem Pharmacol. 2013 Apr 15;85(8):1195-202. doi: 10.1016/j.bcp.2013.01.031.

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