Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000039)
Formula	N-Dehydroxylation; Hydrolysis
	Reactant	Acemetacin	Product	Deacyl indomethacin
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Other reaction - N-Dehydroxylation; Hydrolysis

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR000042	Acemetacin	Indomethacin	Hydrolysis - Esterase Hydrolysis	Acemetacin	[1]
MR000040	Acemetacin	O-demethylatedacemetacin	Oxidation - O-Demethylation	Acemetacin	[1]
MR000041	Acemetacin	O-desmethyl-des-4-chlorobenzoyl	Oxidation - Demethylation	Acemetacin	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001201	Indomethacin	Deacyl indomethacin	Unclear	Indomethacin	[2]

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR000034	Deacyl indomethacin	Deacyl indomethacin glucuronide	Unclear	Acemetacin	[1]
MR001199	Deacyl indomethacin	Deacyl indomethacin glucuronide	Conjugation - Glucuronidation	Indomethacin	[2]
MR001198	Deacyl indomethacin	O-Desmethyl-N-deschlorobenzoyl indomethacin	Oxidation - O-Demethylation	Indomethacin	[2]

References
1	DrugBank(Pharmacology-Metabolism)Acemetacin
2	Comparative in vitro metabolism of phospho-tyrosol-indomethacin by mice, rats and humans Biochem Pharmacol. 2013 Apr 15;85(8):1195-202. doi: 10.1016/j.bcp.2013.01.031.

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