Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001202)
Formula
UGT2B7 ...
SVG example
O-Glucuronidation
Reactant Indomethacin Product Indomethacin acyl glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Metabolic Type Conjugation - O-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001200 Indomethacin 5-hydroxyindomethacin Oxidation - O-Demethylation Indomethacin [1]
MR001201 Indomethacin Deacyl indomethacin Unclear Indomethacin [1]
MR000043 Indomethacin Indometacin glycine Unclear Acemetacin [2]
References
1 Comparative in vitro metabolism of phospho-tyrosol-indomethacin by mice, rats and humans Biochem Pharmacol. 2013 Apr 15;85(8):1195-202. doi: 10.1016/j.bcp.2013.01.031.
2 [Comparative metabolic studies on [14C]-labelled acemetacin and indometacin in rats (author's transl)] Arzneimittelforschung. 1980;30(8A):1384-91.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.