Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001245)
Formula
SVG example
Denitration
Reactant Isosorbide dinitrate Product Isosorbide 5-mononitrate
Reactant Info Product Info
Metabolic Type Other reaction - Denitration
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001246 Isosorbide dinitrate Isosorbide 2-nitrate Other reaction - Denitration Isosorbide dinitrate [1], [2]
MR001247 Isosorbide dinitrate Isosorbide dinitrate Nitric Oxide Unclear Isosorbide dinitrate [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001250 Isosorbide mononitrate Isosorbide mononitrate Nitric Oxide Unclear Isosorbide mononitrate [3], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001243 Isosorbide 5-mononitrate Isosorbide Other reaction - Denitration Isosorbide dinitrate [1], [2]
MR001242 Isosorbide 5-mononitrate Isosorbide-5-mononitrate-2-glucuronide Conjugation - Glucuronidation Isosorbide dinitrate [1], [2]
References
1 Isosorbide dinitrate bioavailability, kinetics, and metabolism Clin Pharmacol Ther. 1985 Aug;38(2):140-9. doi: 10.1038/clpt.1985.150.
2 Pharmacokinetics and metabolism of isosorbide-dinitrate after intravenous and oral administration Eur J Clin Pharmacol. 1985;27(6):637-44. doi: 10.1007/BF00547041.
3 Pharmacokinetics of isosorbide mononitrate Am J Cardiol. 1992 Nov 27;70(17):61G-66G. doi: 10.1016/0002-9149(92)90028-w.
4 Isoforms of cytochrome P450 on organic nitrate-derived nitric oxide release in human heart vessels. FEBS Lett. 1999 Jun 11;452(3):165-9.

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