Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001250)
Formula
ADH5 ...
SVG example
Reactant Isosorbide mononitrate Product Isosorbide mononitrate Nitric Oxide
Reactant Info Product Info
Metabolic Enzyme Alcohol dehydrogenase class-III (ADH5) DME Info
Glutathione S-transferase mu-1 (GSTM1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Putative xanthine dehydrogenase molybdenum-binding subunit XdhA (xdhA) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001249 Isosorbide mononitrate Isosorbide Other reaction - Denitrosylation Isosorbide mononitrate [1]
MR001248 Isosorbide mononitrate Isosorbide-5-mononitrate-2-glucuronide Conjugation - O-Glucuronidation Isosorbide mononitrate [1]
MR001251 Isosorbide mononitrate Sorbitol Other reaction - Denitrosylation Isosorbide mononitrate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001245 Isosorbide dinitrate Isosorbide 5-mononitrate Other reaction - Denitration Isosorbide dinitrate [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001243 Isosorbide 5-mononitrate Isosorbide Other reaction - Denitration Isosorbide dinitrate [2], [3]
MR001242 Isosorbide 5-mononitrate Isosorbide-5-mononitrate-2-glucuronide Conjugation - Glucuronidation Isosorbide dinitrate [2], [3]
References
1 Pharmacokinetics of isosorbide mononitrate Am J Cardiol. 1992 Nov 27;70(17):61G-66G. doi: 10.1016/0002-9149(92)90028-w.
2 Isosorbide dinitrate bioavailability, kinetics, and metabolism Clin Pharmacol Ther. 1985 Aug;38(2):140-9. doi: 10.1038/clpt.1985.150.
3 Pharmacokinetics and metabolism of isosorbide-dinitrate after intravenous and oral administration Eur J Clin Pharmacol. 1985;27(6):637-44. doi: 10.1007/BF00547041.

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