Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001247)
Formula Reactant Isosorbide dinitrate Product Isosorbide dinitrate Nitric Oxide
Reactant Info Product Info
Metabolic Enzyme Glutathione S-transferase mu-1 (GSTM1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001246 Isosorbide dinitrate Isosorbide 2-nitrate Other reaction - Denitration Isosorbide dinitrate [1], [2]
MR001245 Isosorbide dinitrate Isosorbide 5-mononitrate Other reaction - Denitration Isosorbide dinitrate [1], [2]
References
1 Isosorbide dinitrate bioavailability, kinetics, and metabolism Clin Pharmacol Ther. 1985 Aug;38(2):140-9. doi: 10.1038/clpt.1985.150.
2 Pharmacokinetics and metabolism of isosorbide-dinitrate after intravenous and oral administration Eur J Clin Pharmacol. 1985;27(6):637-44. doi: 10.1007/BF00547041.

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