Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001258)
Formula
SVG example
Oxidation
Reactant 4-hydroxy-13-cis-retinoic acid Product 4-oxo-13-cis-retinoic acid
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001262 Isotretinoin 4-hydroxy-13-cis-retinoic acid Oxidation - 4-Hydroxylation Isotretinoin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002989 Alitretinoin 4-oxo-13-cis-retinoic acid Unclear - Unclear Alitretinoin [2]
MR009633 13-cis RA 13-cis-4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [3]
MR001260 4-Oxoretinoic acid 4-oxo-13-cis-retinoic acid Other reaction - Trans-Cis Isomerization Isotretinoin [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001255 4-oxo-13-cis-retinoic acid 4-Oxoretinoic acid Unclear Isotretinoin [4]
References
1 The use of isotretinoin in acne Dermatoendocrinol. 2009 May;1(3):162-9. doi: 10.4161/derm.1.3.9364.
2 The single-dose pharmacokinetics of alitretinoin and its metabolites are not significantly altered in patients with cirrhosis Br J Dermatol. 2014 Feb;170(2):408-14. doi: 10.1111/bjd.12546.
3 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
4 DrugBank(Pharmacology-Metabolism)Isotretinoin

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