Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001255)
Formula
SVG example
Reactant 4-oxo-13-cis-retinoic acid Product 4-Oxoretinoic acid
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002989 Alitretinoin 4-oxo-13-cis-retinoic acid Unclear - Unclear Alitretinoin [1]
MR009633 13-cis RA 13-cis-4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [2]
MR001258 4-hydroxy-13-cis-retinoic acid 4-oxo-13-cis-retinoic acid Oxidation - Oxidation Isotretinoin [3]
MR001260 4-Oxoretinoic acid 4-oxo-13-cis-retinoic acid Other reaction - Trans-Cis Isomerization Isotretinoin [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006383 NSC-122758 4-Oxoretinoic acid Unclear NSC-122758 [4]
MR009627 4-Hydroxyretinoic acid 4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [4], [5]
MR001259 4-hydroxyretinoic acid 4-Oxoretinoic acid Oxidation - Oxidation Isotretinoin [3]
MR005732 Retinoic acid 4-Oxoretinoic acid Unclear Beta carotene [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009628 4-Oxoretinoic acid 4-Oxoretinoic acid glucuronide Conjugation - Glucuronidation Tretinoin [7]
MR001260 4-Oxoretinoic acid 4-oxo-13-cis-retinoic acid Other reaction - Trans-Cis Isomerization Isotretinoin [3]
MR005733 4-Oxoretinoic acid 4-oxo-retinoyl glucuronide Conjugation - Glucuronidation Beta carotene [6]
References
1 The single-dose pharmacokinetics of alitretinoin and its metabolites are not significantly altered in patients with cirrhosis Br J Dermatol. 2014 Feb;170(2):408-14. doi: 10.1111/bjd.12546.
2 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
3 DrugBank(Pharmacology-Metabolism)Isotretinoin
4 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
5 Retinoic acid metabolism and mechanism of action: a review
6 #NAME?
7 Clinical pharmacokinetics of tretinoin

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